Johnson L R
Gastroenterology. 1977 Apr;72(4 Pt.2):788-92.
This paper deals with several new findings regarding the trophic action of gastrointestinal hormones. Naturally occurring gastrins (G-17 I, G-17 II, G-34 II) stimulated DNA synthesis and increased total DNA content of gastric mucosa. These were several times more potent than pentagastrin on a molar basis. In a survey of various tissues from the gastrointestinal tract, pentagastrin exerted trophic effects on mucosa of the oxyntic gland area, duodenum, and colon; it had no effect on the esophagus, antrum, or diaphragm. Maximal stimulation (200% of control) of colonic DNA synthesis was produced by 250 mug of pentagastrin per kg. Vasoactive intestinal peptide did not stimulate DNA synthesis when given alone and inhibited the trophic effect of pentagastrin when administered simultaneously. Glucagon stimulated DNA synthesis in both colon and oxyntic gland mucosa to 40% of the increase caused by pentagastrin and did not inhibit the effects of pentagastrin when administered concurrently.
本文论述了有关胃肠激素营养作用的几项新发现。天然存在的胃泌素（G-17 I、G-17 II、G-34 II）刺激胃黏膜的DNA合成并增加其总DNA含量。在摩尔基础上，这些胃泌素的效力比五肽胃泌素强几倍。在对胃肠道各种组织的一项研究中，五肽胃泌素对胃底腺区、十二指肠和结肠的黏膜发挥营养作用；对食管、胃窦或膈肌则无作用。每千克250微克的五肽胃泌素可使结肠DNA合成产生最大刺激（为对照的200%）。血管活性肠肽单独使用时不刺激DNA合成，与五肽胃泌素同时给药时则抑制其营养作用。胰高血糖素可使结肠和胃底腺黏膜中的DNA合成增加至五肽胃泌素所引起增加量的40%，同时给药时不抑制五肽胃泌素的作用。
