猪促胰液素及在3位和4位修饰的促胰液素类似物的化学和生物学特性

Chemical and biological properties of porcine secretin and secretin analogues modified in positions 3 and 4.

作者信息

König W, Geiger R, Wissmann H, Bickel M, Obermeier R, Teetz W, Uhmann R

出版信息

Gastroenterology. 1977 Apr;72(4 Pt.2):797-800.

Abstract

The synthesis of secretin does not offer fundamental difficulties any longer. The problem of the stability of the hormone seems to be solved from a practical point of view. However, the mechanism of the inactivation of secretin in solution is not yet satisfactorily explained, alpha-beta Rearrangement of the Asp-Gly bond may play a role, but some observations indicate that inactivation is not a straight reaction. Like secretion [Ala-4] secretin shows beta-sympathomimetic activity. The availability of a suitable depot preparation permits physiological studies with secretin and its analogues after subcutaneous administration.

摘要

促胰液素的合成已不再存在根本性困难。从实际角度来看，激素稳定性问题似乎已得到解决。然而，溶液中促胰液素失活的机制尚未得到令人满意的解释，天冬氨酸 - 甘氨酸键的α-β重排可能起作用，但一些观察结果表明失活并非直接反应。像分泌型[丙氨酸 - 4]促胰液素一样表现出β - 拟交感神经活性。合适的长效制剂的可得性使得在皮下给药后能够对促胰液素及其类似物进行生理学研究。