Marini R P, Ryden E B, Rosenblad W D, Murphy J C, Fox J G
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.
J Am Vet Med Assoc. 1993 Feb 1;202(3):430-3.
Functional islet cell tumor was diagnosed in 6 ferrets. Prominent clinical signs included weight loss, hind limb weakness, ptyalism, and tremors. The diagnosis was made on the basis of 2 or more of the following methods and confirmed by histologic examination of biopsied tissue: hypoglycemia on routine serum biochemical analysis, clinical signs of hypoglycemia, simultaneous development of hypoglycemia (44 +/- 9.9 mg/dl; mean +/- SD), and hyperinsulinemia (58 +/- 18.4 microU/ml; mean +/- SD) after food was withheld for 4 hours. Surgical resection of affected tissue was associated with clinical improvement in all cases. Foci of metastasis were found in 1 ferret. Diazoxide was unsuccessful in controlling persistent postsurgical hypoglycemia in 2 ferrets. Additional functional islet cell tumors were identified in 5 of 6 ferrets at necropsy. Functional islet cell tumors are important neoplasms of older ferrets. Preventive health programs for ferrets > 3 years old should include monthly weight determinations and biannual CBC and serum biochemical analysis.
6只雪貂被诊断出患有功能性胰岛细胞瘤。明显的临床症状包括体重减轻、后肢无力、流涎和震颤。诊断基于以下两种或更多方法，并通过活检组织的组织学检查得以证实：常规血清生化分析显示低血糖、低血糖的临床症状、禁食4小时后同时出现低血糖（44±9.9毫克/分升；平均值±标准差）和高胰岛素血症（58±18.4微单位/毫升；平均值±标准差）。所有病例中，手术切除受影响组织后临床症状均有改善。在1只雪貂中发现了转移灶。二氮嗪未能成功控制2只雪貂术后持续的低血糖。尸检时在6只雪貂中的5只发现了其他功能性胰岛细胞瘤。功能性胰岛细胞瘤是老年雪貂的重要肿瘤。对于3岁以上的雪貂，预防性健康计划应包括每月测定体重以及每半年进行一次全血细胞计数和血清生化分析。
