一种促肾上腺皮质激素/促黑素（4-9）类似物可抵消盐皮质激素受体拮抗剂的行为效应。
An ACTH/MSH(4-9) analog counteracts the behavioral effects of a mineralocorticoid receptor antagonist.
作者信息
Oitzl M S, Josephy M, Spruijt B M
机构信息
Center of Bio-Pharmaceutical Sciences, Division of Medical Pharmacology, University of Leiden, The Netherlands.
出版信息
Pharmacol Biochem Behav. 1993 Feb;44(2):447-50. doi: 10.1016/0091-3057(93)90489-g.
The ACTH/MSH(4-9) analog Org2766 has been demonstrated to counteract age-related behavioral and morphological parameters especially those related to hippocampal functioning. Hippocampal mineralocorticoid receptors (MRs) are known to decline in the senescent rat. This decrease can be also counteracted by a chronic treatment with an ACTH(4-9) analog. The apparent effect of the peptide on hippocampal functioning prompted us to study a possible interaction between ACTH and MRs at a behavioral level. A chronic treatment with the ACTH(4-9) analog prevented the behavioral alteration induced by a specific MR antagonist (RU28318; 100 ng/microliters, ICV) in the Morris water maze and a step-through avoidance task. A possible role for neuronal excitation, involving MR activation, in peptide-facilitated behavioral recovery as seen in lesion studies and aging is discussed.
促肾上腺皮质激素/促黑素（4-9）类似物Org2766已被证明可抵消与年龄相关的行为和形态学参数，尤其是那些与海马功能相关的参数。已知海马盐皮质激素受体（MRs）在衰老大鼠中会减少。这种减少也可以通过用促肾上腺皮质激素（4-9）类似物进行长期治疗来抵消。该肽对海马功能的明显作用促使我们在行为水平上研究促肾上腺皮质激素和MRs之间可能的相互作用。用促肾上腺皮质激素（4-9）类似物进行长期治疗可预防在莫里斯水迷宫和一步通过回避任务中由特定MR拮抗剂（RU28318；100纳克/微升，脑室内注射）诱导的行为改变。本文讨论了在损伤研究和衰老中所见的神经元兴奋（涉及MR激活）在肽促进行为恢复中的可能作用。
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