促肾上腺皮质激素/促黑素（4-9）类似物Org2766可改善穹窿海马伞横断术后的信息检索能力。

The ACTH/MSH (4-9) analog Org2766 improves retrieval of information after a fimbria fornix transection.

作者信息

Pitsikas N, Spruijt B M, Algeri S, Gispen W H

机构信息

Division of Molecular Neurobiology, Rudolf Magnus Institute, University of Utrecht, The Netherlands.

出版信息

Peptides. 1990 Sep-Oct;11(5):911-4. doi: 10.1016/0196-9781(90)90008-s.

DOI:10.1016/0196-9781(90)90008-s

PMID:2178248

Abstract

The fimbria fornix of male Wistar rats was transected unilaterally after they had been successfully trained in the Morris maze and the passive avoidance task. Sham-operated and lesioned animals were treated either with Org2766 or saline for two weeks. Subsequently, the performance of all groups was tested again starting two days after the last treatment. The lesioned animals showed a deficit in performance in both tasks, indicating interference of the lesion with retrieval of information. Org2766 improved the poor performance of the lesioned animals in the Morris maze, but not in the passive avoidance task.

摘要

雄性Wistar大鼠在成功完成莫里斯水迷宫和被动回避任务训练后，单侧切断穹窿海马伞。对假手术组和损伤组动物分别给予Org2766或生理盐水处理两周。随后，在最后一次处理两天后开始再次测试所有组的行为表现。损伤组动物在两项任务中的表现均出现缺陷，表明损伤干扰了信息提取。Org2766改善了损伤组动物在莫里斯水迷宫中的不佳表现，但在被动回避任务中没有效果。