Weeds A, Maciver S
MRC Laboratory of Molecular Biology, Cambridge, UK.
Curr Opin Cell Biol. 1993 Feb;5(1):63-9. doi: 10.1016/s0955-0674(05)80009-2.
Recent research on F-actin capping proteins has concentrated on three main areas. The discovery that controlled actin polymerization is the driving force for intracellular movement suggests an important role for capping proteins in regulating filament number and length. A capping protein from Dictyostelium (related to heat-shock protein HSP70) has been characterized that is activated by external stimuli. This provides a pivotal connection between extracellular signalling, cytoskeletal reorganization and locomotory behaviour. The roles of individual actin-binding sites in the gelsolin family of severing/capping proteins and binding sites for phosphatidylinositol 4,5-bisphosphate have been identified.
最近关于F-肌动蛋白封端蛋白的研究主要集中在三个主要领域。有研究发现，受控制的肌动蛋白聚合作用是细胞内运动的驱动力，这表明封端蛋白在调节细丝数量和长度方面具有重要作用。已对一种来自盘基网柄菌的封端蛋白（与热休克蛋白HSP70相关）进行了表征，该蛋白可被外部刺激激活。这在细胞外信号传导、细胞骨架重组和运动行为之间建立了关键联系。已确定了切割/封端蛋白凝溶胶蛋白家族中各个肌动蛋白结合位点的作用以及磷脂酰肌醇4,5-二磷酸的结合位点。
