尼群地平调节心脏（钠，钾）-ATP酶的钠结合位点。
Nitrendipine modulates the sodium binding site of cardiac (Na,K)-ATPase.
作者信息
Dzurba A, Vrbjar N, Ziegelhoffer A
机构信息
Institute for Heart Research, Slovak Academy of Sciences, Bratislava, CSFR.
出版信息
Life Sci. 1993;52(14):1175-9. doi: 10.1016/0024-3205(93)90099-o.
The present study deals with the effect of calcium entry blocking agent, nitrendipine, on the rat heart sarcolemmal (Na,K)-ATPase. Nitrendipine (1 mumol/l) exerted a stimulatory effect on (Na,K)-ATPase activity. Kinetic analysis of enzyme activation by increasing concentrations of sodium in the presence of nitrendipine revealed a 67% increase in Vmax value and a decrease of the apparent Ka value to 33% of that in control. The observed influence on (Na,K)-ATPase may contribute indirectly to the calcium antagonistic effect of nitrendipine.
本研究探讨了钙通道阻滞剂尼群地平对大鼠心肌肌膜（钠，钾）-ATP酶的影响。尼群地平（1微摩尔/升）对（钠，钾）-ATP酶活性具有刺激作用。在尼群地平存在的情况下，通过增加钠浓度对酶激活进行动力学分析，结果显示最大反应速度（Vmax）值增加了67%，表观米氏常数（Ka）值降至对照值的33%。观察到的对（钠，钾）-ATP酶的影响可能间接促成了尼群地平的钙拮抗作用。
Zotero 插件