Prendiville S, Gale K
Department of Pharmacology, Georgetown University Medical Center, Washington, D.C. 20007.
Epilepsia. 1993 Mar-Apr;34(2):381-4. doi: 10.1111/j.1528-1157.1993.tb02425.x.
Fluoxetine was evaluated for anticonvulsant effects in a rat model of focally evoked complex partial seizures (CPS) secondarily generalized. Fluoxetine was administered intraperitoneally (i.p.) 1 h before seizures were induced by focal intracerebral application of the GABAA receptor antagonist, bicuculline methiodide (118 pmol) unilaterally into a discrete epileptogenic site in the deep prepiriform cortex ("area tempestas," AT) of rats. Significant dose-dependent protection from clonic motor seizures was obtained after 5-, 10-, and 20-mg/kg doses of fluoxetine, with 50% protection occurring after the 5-mg/kg dose. Suppression of electrographic seizure activity was concomitant with suppression of motor seizures. These observations support and extend previous findings of other investigators who showed that fluoxetine exerts anticonvulsant actions against maximal electroshock (MES) convulsions and audiogenic convulsions in genetically seizure-prone rodents.
在大鼠局灶性诱发继发性全身性复杂部分性发作（CPS）模型中评估了氟西汀的抗惊厥作用。在通过向大鼠深梨状前皮质（“tempestas区”，AT）中离散的致痫部位单侧局部脑内应用GABAA受体拮抗剂甲磺酸荷包牡丹碱（118 pmol）诱发癫痫发作前1小时，腹腔注射（i.p.）氟西汀。给予5、10和20 mg/kg剂量的氟西汀后，可获得显著的剂量依赖性对阵挛性运动性癫痫发作的保护作用，5 mg/kg剂量后出现50%的保护作用。脑电图癫痫活动的抑制与运动性癫痫发作的抑制同时出现。这些观察结果支持并扩展了其他研究者之前的发现，即氟西汀对遗传性癫痫易感啮齿动物的最大电休克（MES）惊厥和听源性惊厥具有抗惊厥作用。
