Kratz F, Messori L
Department of Chemistry, University of Florence, Italy.
J Inorg Biochem. 1993 Feb 1;49(2):79-82. doi: 10.1016/0162-0134(93)85017-3.
The interaction of ruthenium(III) with human serum transferrin has been investigated through UV/visible and CD spectroscopy. At physiological pH transferrin firmly binds two ruthenium(III) equivalents at the same sites of iron(III). Binding requires the presence of bicarbonate as synergistic anion. Metal uptake from ruthenium(III) nitrilotriacetate is complete within a few minutes; in contrast, uptake from ruthenium(III) chloride does not occur at a significant extent even over a period of days. The chemical properties of the obtained ruthenium/transferrin complex are described.
通过紫外/可见光谱和圆二色光谱研究了钌（III）与人血清转铁蛋白的相互作用。在生理pH值下，转铁蛋白在铁（III）的相同位点牢固结合两个钌（III）当量。结合需要碳酸氢根作为协同阴离子的存在。从次氮基三乙酸钌（III）中摄取金属在几分钟内即可完成；相比之下，即使经过数天，从氯化钌（III）中摄取的量也不显著。描述了所得钌/转铁蛋白复合物的化学性质。
