De Caterina R, Sicari R
Laboratory for Thrombosis and Vascular Research, C.N.R. Institute of Clinical Physiology, Pisa, Italy.
Pharmacol Res. 1993 Jan-Feb;27(1):1-19. doi: 10.1006/phrs.1993.1001.
Thrombin is a key enzyme in the coagulation cascade being the final effector responsible for the conversion of fibrinogen to fibrin. Thrombin as an enzyme also acts on other substrates of the coagulation system, thus resulting in procoagulant tendencies, potentiation of ongoing reactions, feedback inhibition and/or limitation of clotting. Thrombin also has, however, a number of 'cellular' effects probably not only dependent on its enzymatic activity. This review focuses mostly on present knowledge about such mechanisms aimed towards the possible identification and development of molecules able to inhibit the thrombin cellular receptor.
凝血酶是凝血级联反应中的关键酶，是负责将纤维蛋白原转化为纤维蛋白的最终效应物。凝血酶作为一种酶，还作用于凝血系统的其他底物，从而导致促凝倾向、正在进行的反应增强、反馈抑制和/或凝血限制。然而，凝血酶也有许多“细胞”效应，可能不仅取决于其酶活性。本综述主要关注关于此类机制的现有知识，旨在可能鉴定和开发能够抑制凝血酶细胞受体的分子。
