Cameron J C
Yale University School of Nursing.
Cancer Nurs. 1993 Feb;16(1):40-6.
The alkylator-like agent ifosfamide, which has been found to be useful in the treatment of a number of solid tumors, can have severe central nervous system (CNS) side effects in addition to causing myelosuppression, nephrotoxicity, nausea and vomiting, pulmonary edema, and interstitial pneumonitis. This article, including a case study and a protocol, prepares nurses to do patient education and to observe, assess, and provide care for patients who may experience the CNS toxicity that ranges from mild changes to severe disturbances of mental state.
烷化剂样药物异环磷酰胺已被发现可用于治疗多种实体瘤，除了会导致骨髓抑制、肾毒性、恶心和呕吐、肺水肿及间质性肺炎外，还可能产生严重的中枢神经系统（CNS）副作用。本文包括一个案例研究和一份方案，旨在让护士做好患者教育工作，并对可能出现中枢神经系统毒性（从轻度变化到严重精神状态紊乱）的患者进行观察、评估和护理。
