用受体选择性脑啡肽对人类T细胞反应进行免疫调节。
Immunomodulation of human T cell responses with receptor selective enkephalins.
作者信息
Mazumder S, Nath I, Dhar M M
机构信息
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi.
出版信息
Immunol Lett. 1993 Jan;35(1):33-8. doi: 10.1016/0165-2478(93)90144-q.
The delta-opioid receptor selective [2-D-penicillamine-5-D-penicillamine] enkephalin (DPDPE) and the mu receptor selective Tyr-D-Orn-Phe-Asp-NH2 (TOPA) were found respectively, to have marked immunostimulant and immunosuppressant activities in both normal subjects and patients suffering from leprosy and tuberculosis. Antigen specific lymphoproliferation and numbers of rosette forming T cells were significantly (P < 0.05) enhanced on in vitro treatment with Met-enkephalin. This was further increased (P < 0.001) in the presence of the delta selective DPDPE. In contrast, treatment with mu selective TOPA inhibited lymphoproliferation substantially (P < 0.01) and rosette formation to a lesser extent.
分别发现δ阿片受体选择性[2-D-青霉胺-5-D-青霉胺]脑啡肽（DPDPE）和μ受体选择性酪氨酰-D-鸟氨酸-苯丙氨酸-天冬氨酸-酰胺（TOPA）在正常受试者以及麻风病和结核病患者中均具有显著的免疫刺激和免疫抑制活性。用甲硫氨酸脑啡肽进行体外处理后，抗原特异性淋巴细胞增殖以及玫瑰花结形成T细胞的数量显著（P<0.05）增加。在存在δ选择性DPDPE的情况下，这种增加进一步增强（P<0.001）。相反，用μ选择性TOPA处理则会显著抑制淋巴细胞增殖（P<0.01），对玫瑰花结形成的抑制作用较小。
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