Freundt K J
Fortschr Med. 1977 Feb 10;95(6):375-81.
Work-site chemicals are substances which are employed in manufacturing industrial operations. Contact with such materials may present a hazard to health. Substantial hygienic significance is to be attached to the detection of such injurious potentials by experimental and theoretical toxicology. The preparation of toxicologic expertises on industrial materials presents many problems. The standard approach is to utilize scientific methods on the basis of defined experimental models and quantitative relationships. Judgment of the toxicologic relevance is guided by well-documented epidemiologic or experimental data and the study of case histories. After scientific validation the result is used in practice for setting threshold limit values (MAK's, MIK's) for occupational health purposes.
工作场所化学品是指在工业生产操作中使用的物质。接触此类物质可能对健康构成危害。通过实验和理论毒理学检测此类潜在危害具有重大的卫生学意义。编写关于工业材料的毒理学专业报告存在诸多问题。标准方法是基于既定的实验模型和定量关系运用科学方法。毒理学相关性的判断以充分记录的流行病学或实验数据以及病例史研究为指导。经过科学验证后，结果应用于实践，以确定职业健康目的的阈限值（MAK、MIK）。
