[静脉注射吸毒者感染人类免疫缺陷病毒以及乙型、丙型和丁型肝炎病毒。1年时的血清流行率及其随访情况]

[Infection by HIV and the hepatitis B, C, and D viruses in intravenous drug addicts. Seroprevalence at 1 year and its follow-up].

作者信息

Delgado-Iribarren A, Wilhelmi I, Padilla B, Cañedo T, Gómez J, Elviro J

机构信息

Servicio de Microbiología, Hospital Severo Ochoa, Leganés, Madrid.

出版信息

Enferm Infecc Microbiol Clin. 1993 Jan;11(1):8-13.

PMID:8384891

Abstract

BACKGROUND

The aim of the present article was to study the serology of intravenous drug user patients against the hepatitis B, C, D, and HIV, during 1990 and the follow-up during the same year, and 1991.

METHODS

A study of 265 patients (mean age: 25 years, range: 16-45; 206 males and 59 females) was carried out. Forty-two percent came because of detoxication treatment, 30% requested diagnosis for hepatic disturbances and the only data provided in 28% were that they were intravenous drug users. None of the patients was an inmate from prisons.

RESULTS

Seroprevalences were 67.5% for the HBV, 75.6% for HCV, 17% for HDV and 50.2% for HIV. In the patients seronegative for HBV (65%) and HIV (58%) no new serologic controls were performed during the study period, while in those who underwent controls the rates of seroconversion were 43.3% and 32%, respectively. In 30% of all seroconversions to HBV coinfection with HDV was found and in 23% antibodies against HIV were observed.

CONCLUSIONS

Due to the high rates of infection obtained, the authors believe that serologic follow up of intravenous drug users is advisable.

摘要

背景

本文旨在研究1990年静脉吸毒患者针对乙型、丙型、丁型肝炎及艾滋病毒的血清学情况，以及同年和1991年的随访情况。

方法

对265例患者（平均年龄：25岁，范围：16 - 45岁；男性206例，女性59例）进行了研究。42%的患者因戒毒治疗前来，30%要求诊断肝脏疾病，28%仅提供了他们是静脉吸毒者这一信息。所有患者均非监狱服刑人员。

结果

乙肝病毒（HBV）血清阳性率为67.5%，丙肝病毒（HCV）为75.6%，丁肝病毒（HDV）为17%，艾滋病毒（HIV）为50.2%。在乙肝病毒血清阴性（65%）和艾滋病毒血清阴性（58%）的患者中，研究期间未进行新的血清学检查，而在接受检查的患者中，血清转化率分别为43.3%和32%。在所有乙肝病毒血清转化患者中，30%发现合并丁肝病毒感染，23%检测到抗艾滋病毒抗体。