Davis B K
Int J Fertil. 1976(2):123-6.
Placement of two 1 cm copper (Cu) coils around the mid-region of each oviduct in a group of five female rabbits with proven fertility, 34 days before mating, virtually prevented fetal implantation in these animals. The oviducts remained patent during a 47 day implantation period and following removal of the Cu coils, does that were remated became pregnant. In two of these does an implantation rate (living fetuses/corpora lutea) of 33% (7/21) was observed and one post-Cu implanted doe had a litter of two. Among four does bearing a single Cu coil on their left oviduct for 28 days prior to mating there was 19% (4/21) implantation of the left side and 56.3% (9/16) on the untreated right side, suggesting a local action by the metal. The results indicate that Cu is an effective anti-fertility agent when implanted around the oviducts and, as a corollary, it is apparent that the metal is not restricted to placement in the uterus in order to prevent pregnancy in rabbits. Non-occluding Cu containing devices may offer a new approach to reversible fertility control in the female that merits further investigation.
在一组五只经证实具有生育能力的雌性兔子中，在交配前34天，于每条输卵管中部周围放置两个1厘米的铜（Cu）线圈，实际上可防止这些动物发生胎儿着床。在47天的着床期内，输卵管保持通畅，去除铜线圈后，再次交配的母兔受孕。在其中两只母兔中，观察到着床率（存活胎儿/黄体）为33%（7/21），一只铜线圈植入后着床的母兔产下一窝两只幼崽。在四只母兔中，于交配前28天在其左侧输卵管上放置单个铜线圈，左侧着床率为19%（4/21），未处理的右侧着床率为56.3%（9/16），表明金属具有局部作用。结果表明，铜植入输卵管周围时是一种有效的抗生育剂，并且由此可见，为防止兔子怀孕，该金属不限于放置在子宫内。不含阻塞物的含铜装置可能为女性可逆性生育控制提供一种新方法，值得进一步研究。
