Nakazawa T, Hijikata M, Kato N, Shimotohno K
Nihon Rinsho. 1993 Feb;51(2):318-22.
Hepatitis C virus (HCV) genomes show sequence diversities among virus isolates. In particular, the putative envelope region encoding gp35 and gp70 shows on extensive sequence diversity in the whole viral genome. We identified two hypervariable regions [HVR1 (27 amino acids) and HVR2 (7 amino acids)] in the N-terminal region of gp70 of the HCV-II genotype. In the HCV-I genotype, extensive diversity of amino acid sequence in HVR1 is also observed in the same region (21 amino acids), but such diversity in HVR2 is not clearly observed like HCV-II genotype. In addition, the alteration of amino acids in HVR1 was also observed in patients with chronic hepatitis. It is suggested mutation in HVR1 is involved in the mechanism of persistent HCV infection.
丙型肝炎病毒（HCV）基因组在病毒分离株之间表现出序列多样性。特别是，编码gp35和gp70的假定包膜区域在整个病毒基因组中表现出广泛的序列多样性。我们在HCV-II基因型gp70的N端区域鉴定出两个高变区[HVR1（27个氨基酸）和HVR2（7个氨基酸）]。在HCV-I基因型中，在同一区域（21个氨基酸）也观察到HVR1中氨基酸序列的广泛多样性，但在HVR2中没有像HCV-II基因型那样明显观察到这种多样性。此外，在慢性肝炎患者中也观察到HVR1中氨基酸的改变。提示HVR1中的突变参与了HCV持续感染的机制。
