Heinic G S, Northfelt D W, Greenspan J S, MacPhail L A, Greenspan D
Department of Stomatology and Oral AIDS Center, University of California, San Francisco.
Oral Surg Oral Med Oral Pathol. 1993 Apr;75(4):488-94. doi: 10.1016/0030-4220(93)90176-5.
Recurrent oral herpes simplex virus lesions are common in both immunocompetent and immunocompromised persons. In contrast, cytomegalovirus-associated intraoral lesions are rarely seen, even in the immunocompromised host. We report a case of concurrent oral herpes simplex virus and cytomegalovirus infection, appearing as an ulcerative lesion of the labial mucosa in a patient with acquired immunodeficiency syndrome. Herpes simplex virus type 1 was shown to be present in the lesion by culture tests, histopathologic examination, immunohistochemistry findings and a direct immunofluorescence assay, and cytomegalovirus by histopathologic examination and immunohistochemistry findings. We deduce that the lesion was due to concurrent herpes simplex virus-1 and cytomegalovirus infection. The patient responded well to 2 weeks of treatment with a high dose of acyclovir.
复发性口腔单纯疱疹病毒病变在免疫功能正常和免疫功能低下的人群中都很常见。相比之下，即使在免疫功能低下的宿主中，巨细胞病毒相关的口腔内病变也很少见。我们报告一例获得性免疫缺陷综合征患者同时发生口腔单纯疱疹病毒和巨细胞病毒感染，表现为唇黏膜溃疡性病变。通过培养试验、组织病理学检查、免疫组化结果和直接免疫荧光测定证实病变中存在1型单纯疱疹病毒，通过组织病理学检查和免疫组化结果证实存在巨细胞病毒。我们推断该病变是由1型单纯疱疹病毒和巨细胞病毒同时感染引起的。患者接受高剂量阿昔洛韦治疗2周后反应良好。
