Gnaore E, Sassan-Morokro M, Kassim S, Ackah A, Yesso G, Adjorlolo G, Digbeu H, Coulibaly D, Coulibaly I M, Doorly R
Project RETRO-CI, Abidjan, Côte d'Ivoire.
Trans R Soc Trop Med Hyg. 1993 Jan-Feb;87(1):57-9. doi: 10.1016/0035-9203(93)90420-u.
Between July 1989 and December 1990, 4504 new adult patients with tuberculosis were screened for antibodies to human immunodeficiency viruses (HIV) 1 and 2 in Abidjan's 2 tuberculosis treatment centres. The prevalence levels of HIV-1 and HIV-2 infections were 30.2% and 4.2% respectively, a further 9.3% of patients reacting serologically to both viruses. Patients in all 3 seropositive groups differed significantly from seronegatives in having a higher frequency of AIDS-related features such as wasting, chronic diarrhoea, oral candidiasis and generalized lymphadenopathy. These data support earlier work showing an association between HIV-2 infection and similar opportunistic diseases which complicate HIV-1 infection, including tuberculosis. Despite the differences between seropositive and seronegative groups, symptoms and signs of tuberculosis may mimic those of AIDS. HIV testing should be more widely available for the clinical care of tuberculosis patients in Africa, as well as for epidemiological surveillance.
1989年7月至1990年12月期间，在阿比让的2个结核病治疗中心，对4504名新成年结核病患者进行了人类免疫缺陷病毒（HIV）1型和2型抗体筛查。HIV-1和HIV-2感染的流行率分别为30.2%和4.2%，另有9.3%的患者对两种病毒血清学反应均呈阳性。所有3个血清反应阳性组的患者与血清反应阴性组相比，出现消瘦、慢性腹泻、口腔念珠菌病和全身淋巴结病等与艾滋病相关特征的频率明显更高。这些数据支持了早期的研究结果，即HIV-2感染与使HIV-1感染复杂化的类似机会性疾病（包括结核病）之间存在关联。尽管血清反应阳性组和血清反应阴性组存在差异，但结核病的症状和体征可能与艾滋病相似。在非洲，应更广泛地开展HIV检测，以便对结核病患者进行临床护理以及开展流行病学监测。
