Cooperative hydrogen ligand binding inducing the Bohr effect in human hemoglobin. A general methodology.
作者信息
Forlani L, Marini M A
机构信息
Dipartimento di Medicina Sperimentale, Facolta' di Medicina, Universita' La Sapienza, Rome, Italy.
出版信息
Cell Mol Biol (Noisy-le-grand). 1993 Feb;39(1):21-34.
PMID:8385518
Abstract
A cooperative model applied to hydrogen ligand binding curves of normal human hemoglobin indicates that the Bohr effect is a cooperative (n) change rather than a pK shift. The analysis suggests a molecular mechanism whose energetic justification acquires a specific physiological significance.
摘要
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