神经激肽A受体激动剂诱导小鼠的转向行为：非肽类受体拮抗剂SR 48968的立体选择性阻断作用

Turning behavior induced in mice by a neurokinin A receptor agonist: stereoselective blockade by SR 48968, a non-peptide receptor antagonist.

作者信息

Poncelet M, Gueudet C, Emonds-Alt X, Brelière J C, Le Fur G, Soubrié P

机构信息

Sanofi Recherche, Montpellier, France.

出版信息

Neurosci Lett. 1993 Jan 4;149(1):40-2. doi: 10.1016/0304-3940(93)90342-i.

DOI:10.1016/0304-3940(93)90342-i

PMID:8385752

Abstract

The intrastriatal injection of [Nle10]-NKA(4-10), a neurokinin A agonist, (0.05-5 ng/mouse) elicited vigorous contralateral rotations. This behavior was dose-dependently antagonized by SR 48968 (ED50: 0.15 mg/kg i.p.: 0.19 mg/kg p.o.), a selective non-peptide antagonist of NK-2 receptors, but it was not affected by spiroperidol. This suggests that NK-2 receptor stimulation may affect the activity of the striatum without necessarily involving dopaminergic systems.

摘要

向纹状体内注射神经激肽A激动剂[Nle10]-NKA(4 - 10)(0.05 - 5 ng/小鼠)会引发强烈的对侧旋转。这种行为可被SR 48968（腹腔注射半数有效剂量：0.15 mg/kg；口服半数有效剂量：0.19 mg/kg）剂量依赖性地拮抗，SR 48968是一种选择性非肽类NK - 2受体拮抗剂，但不受螺哌啶的影响。这表明刺激NK - 2受体可能影响纹状体的活性，而不一定涉及多巴胺能系统。