• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Effect of alternating combination chemotherapy consisting of cyclophosphamide, doxorubicin, vincristine, cisplatin, and etoposide for small cell lung cancer on hematopoietic progenitors in the peripheral blood.环磷酰胺、阿霉素、长春新碱、顺铂和依托泊苷交替联合化疗对小细胞肺癌患者外周血造血祖细胞的影响
Br J Cancer. 1993 Apr;67(4):798-800. doi: 10.1038/bjc.1993.145.
2
A randomized trial of hybrid administration of cyclophosphamide, doxorubicin, and vincristine (CAV)/cisplatin and etoposide (PVP) versus sequential administration of CAV-PVP for the treatment of patients with small cell lung carcinoma: results of long term follow-up.环磷酰胺、阿霉素和长春新碱（CAV）/顺铂与依托泊苷（PVP）混合给药对比CAV-PVP序贯给药治疗小细胞肺癌患者的随机试验：长期随访结果
Cancer. 1998 Jul 15;83(2):283-90.
3
Alternating chemotherapy with cyclophosphamide/adriamycin/vincristine (CAV) and cisplatin/etoposide (PVP) against small cell lung cancer. Eastern Shikoku Lung Cancer Chemotherapy Group.
Jpn J Clin Oncol. 1991 Dec;21(6):435-9.
4
Granulocyte-colony-stimulating factor enhances the circulating hematopoietic progenitors in lung cancer patients treated with cisplatin-containing regimens.粒细胞集落刺激因子可增强接受含顺铂方案治疗的肺癌患者循环中的造血祖细胞数量。
Jpn J Cancer Res. 1992 Jul;83(7):746-53. doi: 10.1111/j.1349-7006.1992.tb01975.x.
5
Combined modality therapy for small cell lung cancer.
Oncology. 1992;49 Suppl 1:2-9; discussion 10. doi: 10.1159/000227103.
6
Phase III study of intensive weekly chemotherapy with recombinant human granulocyte colony-stimulating factor versus standard chemotherapy in extensive-disease small-cell lung cancer. The Japan Clinical Oncology Group.重组人粒细胞集落刺激因子强化每周化疗与标准化疗治疗广泛期小细胞肺癌的III期研究。日本临床肿瘤学会。
J Clin Oncol. 1998 Jun;16(6):2126-32. doi: 10.1200/JCO.1998.16.6.2126.
7
Randomized trial of cyclophosphamide, doxorubicin, and vincristine versus cisplatin and etoposide versus alternation of these regimens in small-cell lung cancer.环磷酰胺、阿霉素和长春新碱联合用药与顺铂和依托泊苷联合用药及这两种方案交替使用治疗小细胞肺癌的随机试验
J Natl Cancer Inst. 1991 Jun 19;83(12):855-61. doi: 10.1093/jnci/83.12.855.
8
Randomized study of CODE versus alternating CAV/EP for extensive-stage small-cell lung cancer: an Intergroup Study of the National Cancer Institute of Canada Clinical Trials Group and the Southwest Oncology Group.CODE方案与交替CAV/EP方案治疗广泛期小细胞肺癌的随机研究：加拿大国立癌症研究所临床试验组与西南肿瘤学组的一项组间研究
J Clin Oncol. 1999 Aug;17(8):2300-8. doi: 10.1200/JCO.1999.17.8.2300.
9
Etoposide combined with cyclophosphamide plus vincristine compared with doxorubicin plus cyclophosphamide plus vincristine and with high-dose cyclophosphamide plus vincristine in the treatment of small-cell carcinoma of the lung: a randomized trial of the Bristol Lung Cancer Study Group.依托泊苷联合环磷酰胺加长春新碱与多柔比星联合环磷酰胺加长春新碱以及高剂量环磷酰胺加长春新碱治疗小细胞肺癌的比较：布里斯托尔肺癌研究组的一项随机试验
J Clin Oncol. 1989 Apr;7(4):450-6. doi: 10.1200/JCO.1989.7.4.450.
10
Alternating combination chemotherapy regimens in small-cell lung cancer.
Semin Oncol. 1985 Mar;12(1 Suppl 2):7-13.

本文引用的文献

1
Rationale for the use of alternating non-cross-resistant chemotherapy.使用交替性非交叉耐药化疗的理论依据。
Cancer Treat Rep. 1982 Mar;66(3):439-49.
2
Amplification of circulating granulocyte-monocyte stem cell numbers following chemotherapy in patients with extensive small cell carcinoma of the lung.
Cancer Res. 1981 Jan;41(1):35-41.
3
Superiority of alternating non-cross-resistant chemotherapy in extensive small cell lung cancer. A multicenter, randomized clinical trial by the National Cancer Institute of Canada.交替使用非交叉耐药化疗方案治疗广泛期小细胞肺癌的优越性。加拿大国家癌症研究所进行的一项多中心随机临床试验。
Ann Intern Med. 1987 Oct;107(4):451-8. doi: 10.7326/0003-4819-107-4-451.
4
Differential activity of recombinant colony-stimulating factors in supporting proliferation of human peripheral blood and bone marrow myeloid progenitors in culture.重组集落刺激因子在支持培养的人外周血和骨髓髓系祖细胞增殖方面的差异活性。
Br J Haematol. 1989 Jul;72(3):306-11. doi: 10.1111/j.1365-2141.1989.tb07709.x.
5
Circulating hematopoietic progenitors in patients with primary lung cancer.原发性肺癌患者循环中的造血祖细胞。
Jpn J Cancer Res. 1990 Dec;81(12):1293-9. doi: 10.1111/j.1349-7006.1990.tb02693.x.
6
Single high doses of cyclophosphamide enable the collection of high numbers of hemopoietic stem cells from the peripheral blood.单次大剂量环磷酰胺可使从外周血中采集到大量造血干细胞。
Exp Hematol. 1990 Jun;18(5):442-7.
7
Peripheral blood expansion of early progenitor cells after high-dose cyclophosphamide and rhGM-CSF.大剂量环磷酰胺和重组人粒细胞巨噬细胞集落刺激因子后早期祖细胞在外周血中的扩增。
Eur J Cancer. 1991;27(1):22-7. doi: 10.1016/0277-5379(91)90052-f.
8
Flow cytometry for clinical estimation of circulating hematopoietic progenitors for autologous transplantation in cancer patients.流式细胞术用于癌症患者自体移植中循环造血祖细胞的临床评估。
Blood. 1991 Jan 15;77(2):400-9.
9
Effects of recombinant human G-CSF, GM-CSF, IL-3, and IL-1 alpha on the growth of purified human peripheral blood progenitors.重组人粒细胞集落刺激因子、粒细胞-巨噬细胞集落刺激因子、白细胞介素-3和白细胞介素-1α对纯化的人外周血祖细胞生长的影响。
Blood. 1990 Jul 15;76(2):330-5.
10
Autologous blood stem cell harvesting and transplantation in patients with advanced ovarian cancer.晚期卵巢癌患者的自体造血干细胞采集与移植
Br J Haematol. 1991 Nov;79(3):444-50. doi: 10.1111/j.1365-2141.1991.tb08053.x.

环磷酰胺、阿霉素、长春新碱、顺铂和依托泊苷交替联合化疗对小细胞肺癌患者外周血造血祖细胞的影响

Effect of alternating combination chemotherapy consisting of cyclophosphamide, doxorubicin, vincristine, cisplatin, and etoposide for small cell lung cancer on hematopoietic progenitors in the peripheral blood.

作者信息

Shimizu E, Yamamoto A, Takahashi Y, Maniwa K, Yoshida S, Mukai J, Takaue Y, Ogura T

机构信息

Third Department of Internal Medicine, University of Tokushima School of Medicine, Japan.

出版信息

Br J Cancer. 1993 Apr;67(4):798-800. doi: 10.1038/bjc.1993.145.

DOI:10.1038/bjc.1993.145
PMID:8385979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1968335/
Abstract

The effects of a combination chemotherapy (CAV-PVP) consisting of cyclophosphamide, doxorubicin, hydrochloride (dox) and vincristine (CAV) alternating with cisplatin and etoposide (PVP) on peripheral blood hematopoietic progenitor cells (PBHPs) were studied in five patients with small cell lung cancer (SCLC). The kinetics of the CFU-GM levels were different during the CAV and PVP phases. None of the five patients displayed a rebound increase in the level of peripheral blood CFU-GM during the CAV phase. In contrast, all five patients displayed a rebound increase in peripheral blood CFU-GM levels during the PVP phase of the alternative combination chemotherapy (3-5 weeks after the initiation of PVP regimen). These findings indicate the optimal timing for leukapheresis to obtain PBHPs in SCLC patients which have been treated with an alternating combination chemotherapy consisting of CAV-PVP.

摘要

在5例小细胞肺癌（SCLC）患者中研究了由环磷酰胺、阿霉素（多柔比星）、盐酸多柔比星和顺铂交替使用的联合化疗方案（CAV-PVP）对外周血造血祖细胞（PBHP）的影响。在CAV期和PVP期，CFU-GM水平的动力学不同。5例患者在CAV期外周血CFU-GM水平均未出现反弹升高。相反，在交替联合化疗的PVP期（PVP方案开始后3-5周），所有5例患者外周血CFU-GM水平均出现反弹升高。这些发现表明了在接受CAV-PVP交替联合化疗的SCLC患者中进行白细胞单采获取PBHP的最佳时机。