Pritchard D J, Reiman H M, Turcotte R E, Ilstrup D M
Department of Orthopedics, Mayo Clinic, Rochester, Minnesota 55905.
Clin Orthop Relat Res. 1993 Apr(289):58-65.
Malignant fibrous histiocytoma (MFH) is the most commonly diagnosed soft-tissue sarcoma. Of 408 retrospectively reviewed patients with MFH, 220 patients had primary, localized, previously untreated tumors involving the extremities or limb girdles. Univariate statistical analysis of results revealed five prognostic factors that were significantly related to poor outcome: old age, deeply seated lesions, surgical grade, large size, and marginal or intralesional surgery. Multivariate analysis revealed only three factors that were significantly related to poor prognosis: old age, deeply seated lesions, and inadequate surgery.
恶性纤维组织细胞瘤（MFH）是最常被诊断出的软组织肉瘤。在408例接受回顾性研究的MFH患者中，220例患者患有原发性、局限性、此前未接受过治疗的肿瘤，病变累及四肢或肢带。对结果进行的单因素统计分析显示，有五个预后因素与不良结局显著相关：高龄、病变位置深、手术分级、肿瘤体积大，以及边缘性或病灶内手术。多因素分析显示，只有三个因素与预后不良显著相关：高龄、病变位置深，以及手术不充分。
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