大鼠腰段背根神经节急性单纯疱疹病毒感染的免疫组织学特征
Immunohistological characterisation of acute herpes simplex virus infection of lumbar dorsal root ganglia in the rat.
作者信息
Blondeau J M, Aoki F Y, Nagy J I
机构信息
Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, Canada.
出版信息
J Med Microbiol. 1993 Apr;38(4):265-9. doi: 10.1099/00222615-38-4-265.
After inoculation of herpes simplex virus (HSV) into the dorsal skin of the hind paw of rats, HSV antigen was detected in dorsal root ganglion neurones by immunohistochemistry. Antigen was first detected 2 days after inoculation. Between 2 and 4 days after inoculation, numerous small-type unmyelinated neurones gave positive staining reactions for HSV antigens. Necrosis of neuronal cells was evident by 4 days. Antigen was not detected 6 or 9 days after inoculation. Immunohistological studies of co-cultivated ganglia removed from the infected monolayers, immediately after cytopathic effect first appeared or 24 h later, uniformly revealed virus antigen staining of small-type unmyelinated neuronal cells.
将单纯疱疹病毒（HSV）接种到大鼠后爪背部皮肤后，通过免疫组织化学在背根神经节神经元中检测到HSV抗原。接种后2天首次检测到抗原。接种后2至4天，许多小型无髓神经元对HSV抗原呈阳性染色反应。到4天时神经元细胞坏死明显。接种后6天或9天未检测到抗原。对感染单层细胞出现细胞病变效应后立即或24小时后从感染单层细胞中取出的共培养神经节进行免疫组织学研究，均显示小型无髓神经元细胞有病毒抗原染色。
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