Uyemura K
Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
Neurosci Res. 1993 Jan;16(1):9-13. doi: 10.1016/0168-0102(93)90003-9.
Certain types of glycoproteins expressed in Schwann cell appear to play specific roles in neurite growth and neural migration. Peripheral myelin protein-22 (PMP-22) is a glycoprotein down-regulated in nerve damage and is involved in both trembler mouse mutation and human Charcot-Marie-Tooth disease, type 1A. PMP-22 now appears to be a homologue of previously reported PASII. The homology of PASII/PMP-22 to the growth arrest-specific protein (Gas-3) suggests its role in Schwann cell development. P0, a major protein in peripheral myelin, mediates cell adhesion and promotes neurite outgrowth. In cell adhesion mediated by P0, its unique carbohydrate chain plays an important role. A special isoform of L1 (L1cs), with a short deletion in the intracellular domain, is localized in Schwann cells, whilst the complete L1 is exclusively located in neurons. L1cs in Schwann cells may function differently from L1 in neurons.
施万细胞中表达的某些类型糖蛋白似乎在神经突生长和神经迁移中发挥特定作用。外周髓鞘蛋白-22（PMP-22）是一种在神经损伤中下调的糖蛋白，与震颤小鼠突变和1A型人类夏科-马里-图思病都有关。PMP-22现在似乎是先前报道的PASII的同源物。PASII/PMP-22与生长停滞特异性蛋白（Gas-3）的同源性表明其在施万细胞发育中的作用。P0是外周髓鞘中的主要蛋白，介导细胞黏附并促进神经突生长。在由P0介导的细胞黏附中，其独特的糖链起重要作用。L1的一种特殊同工型（L1cs），细胞内结构域有短缺失，定位于施万细胞，而完整的L1仅位于神经元中。施万细胞中的L1cs可能与神经元中的L1功能不同。
