Boleaga B, Fanghänel G, Cortinas L, Valdés E, Vargas E, Velasco F
Hypothalamus-Hypophysis Clinic, Hospital General de México, D.F.
Rev Invest Clin. 1993 Jan-Feb;45(1):37-42.
To assess the usefulness of Gd-DTPA enhancement in disclosing microadenomas of the pituitary gland that had not been demonstrated by non enhanced MRI in patients with Cushing's disease.
Six patients with Cushing's disease underwent pre and post enhancement MRI scanning and the findings were correlated at surgery and confirmed by histological and immunohistochemistry studies of the surgical specimen.
In all cases post enhancement MR scans demonstrated circumscribed hypointense foci that corresponded well with the location and extension of the adenomatous tissue found at surgery. Selective removal of the microadenomas failed to improve the clinical and laboratory abnormalities in two of the six patients. Such cases did not present residual hypointense foci in the post-operative Gd-DTPA enhanced MRI.
Results suggest that Gd-DTPA enhanced MRI is useful to detect pituitary microadenomas; however, the abnormalities of the pituitary tissue may extend beyond the abnormal imaging.
评估钆喷酸葡胺（Gd-DTPA）增强扫描在显示库欣病患者垂体微腺瘤方面的作用，这些微腺瘤在非增强MRI中未显示。
6例库欣病患者接受了增强前后的MRI扫描，检查结果与手术情况相关，并通过手术标本的组织学和免疫组织化学研究得到证实。
在所有病例中，增强后的MR扫描均显示出边界清晰的低信号灶，与手术中发现的腺瘤组织的位置和范围高度吻合。6例患者中有2例选择性切除微腺瘤后，临床和实验室异常情况未得到改善。此类病例在术后Gd-DTPA增强MRI中未出现残留的低信号灶。
结果表明，Gd-DTPA增强MRI有助于检测垂体微腺瘤；然而，垂体组织的异常可能超出异常影像学表现的范围。
