Coy P, Thomas J W, Hasham N
J Can Assoc Radiol. 1977 Mar;28(1):43-8.
Lymphocyte mitogen transformation has been studied before and after treatment with sugery and radiation in lung cancer patients, in surgically treated patients with non-malignant lesions, and in healthy persons. We have shown a fall in lymphocyte response following operation, even in patients with benign lesions. Patients with cancer have a lymphocyte response which is depressed following operation more than the patients with benign lesions. Following cobalt irradiation there is a further fall in response. We were not able to identify a factor in the serum of patient with depressed lymphocyte transfromation which affected lymphocyte response to Phytohemagglutinin. A recovery in response towards pre-treatment levels occurs earliest in patients with benign lesions. In the patients who had not received irradiation, lymphocyte transformation did not have any prognostic value. In patients with advancing cancer, who ultimately die following irradiation, there is no recovery of response. This lack of recovery signals a very poor prognosis.
对肺癌患者、接受手术治疗的非恶性病变患者以及健康人在手术和放疗前后的淋巴细胞有丝分裂原转化情况进行了研究。我们发现，即使是良性病变患者，术后淋巴细胞反应也会下降。癌症患者术后淋巴细胞反应的抑制程度比良性病变患者更严重。钴照射后反应进一步下降。我们未能在淋巴细胞转化受抑制的患者血清中鉴定出影响淋巴细胞对植物血凝素反应的因素。良性病变患者的反应最早恢复到治疗前水平。在未接受照射的患者中，淋巴细胞转化没有任何预后价值。在癌症进展期且最终因照射死亡的患者中，反应没有恢复。这种缺乏恢复表明预后非常差。
