17号染色体等位基因缺失见于肝细胞癌，但不见于同期肝腺瘤。
Chromosome 17 allele loss in hepatocellular carcinoma but not in synchronous liver adenoma.
作者信息
Ding S F, Jalleh R P, Dooley J, Wood C B, Habib N A
机构信息
Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
出版信息
Eur J Surg Oncol. 1993 Apr;19(2):195-7.
PMID:8387935
Abstract
A 51-year-old female underwent resection of two synchronous liver tumours, a hepatocellular carcinoma and an adenoma. DNA analysis revealed allele loss on chromosome 17 (17p13, near the locus of p53 tumour suppressor gene) in the hepatocellular carcinoma but not in the adenoma. This finding may support the view that loss of p53 tumour suppressor gene is associated with tumour progression.
摘要
一名51岁女性接受了两个同时性肝肿瘤的切除术，一个是肝细胞癌，另一个是腺瘤。DNA分析显示，肝细胞癌中17号染色体（17p13，靠近p53肿瘤抑制基因位点）存在等位基因缺失，而腺瘤中没有。这一发现可能支持p53肿瘤抑制基因缺失与肿瘤进展相关的观点。
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