Takahashi K, Kudo J, Ishibashi H, Hirata Y, Niho Y
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Hepatology. 1993 May;17(5):794-9.
We investigated 24 hepatocellular carcinomas in Japan to find loss of heterozygosity with 15 polymorphic DNA markers that detect allelic losses at specific chromosome loci. Loss of heterozygosity on chromosomes 10q, 17p and 22q was detected in 3 of 12 (25%), 9 of 21 (43%) and 5 of 15 (33%) informative cases of hepatocellular carcinoma, respectively. This is the first report of loss of heterozygosity on chromosome 22q in hepatocellular carcinoma; the newly recognized common chromosome loss was considered to exist between D22S9 and D22S10 on 22q11. On the basis of this and other studies, we believe it is likely that such a chromosome loss in hepatocellular carcinoma is a signal for malignant transformation and that loss of unknown genes on chromosomes 10q, 17p and 22q may contribute to tumor progression in hepatocellular carcinoma.
我们对日本的24例肝细胞癌进行了研究，以利用15个多态性DNA标记来检测特定染色体位点的等位基因缺失，从而发现杂合性缺失情况。在12例信息充分的肝细胞癌病例中，分别有3例（25%）、21例中的9例（43%）和15例中的5例（33%）检测到10q、17p和22q染色体上的杂合性缺失。这是关于肝细胞癌22q染色体杂合性缺失的首次报道；新确认的常见染色体缺失被认为存在于22q11上的D22S9和D22S10之间。基于此项研究及其他研究，我们认为肝细胞癌中的这种染色体缺失很可能是恶性转化的一个信号，并且10q、17p和22q染色体上未知基因的缺失可能有助于肝细胞癌的肿瘤进展。
