Sharma R K, Kalra J
Department of Pathology, College of Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, Canada.
Biochemistry. 1993 May 18;32(19):4975-8. doi: 10.1021/bi00070a001.
The effects of various ginsenosides on calmodulin-dependent phosphodiesterase isozymes have been investigated. Ginsenosides were found to be potent inhibitors of bovine heart calmodulin-dependent phosphodiesterase and the 60-kDa isozyme of bovine brain calmodulin-dependent phosphodiesterase but not of the 63-kDa isozyme of bovine brain calmodulin-dependent phosphodiesterase. Since the inhibition of phosphodiesterase by ginsenosides was overcome by increasing the concentration of calmodulin, this suggests that ginsenosides act specifically and reversibly against the action of the calmodulin. These compounds therefore should be valuable tools to investigate the diverse physiological roles of distinct phosphodiesterase isozymes.
已对各种人参皂苷对钙调蛋白依赖性磷酸二酯酶同工酶的作用进行了研究。发现人参皂苷是牛心钙调蛋白依赖性磷酸二酯酶和牛脑钙调蛋白依赖性磷酸二酯酶60 kDa同工酶的有效抑制剂，但不是牛脑钙调蛋白依赖性磷酸二酯酶63 kDa同工酶的抑制剂。由于增加钙调蛋白浓度可克服人参皂苷对磷酸二酯酶的抑制作用，这表明人参皂苷对钙调蛋白的作用具有特异性且可逆。因此，这些化合物应是研究不同磷酸二酯酶同工酶多种生理作用的有价值工具。
