胰岛素依赖型糖尿病患者血小板内cGMP水平较低。
Low levels of intraplatelet cGMP in IDDM.
作者信息
Amado J A, Salas E, Botana M A, Poveda J J, Berrazueta J R
机构信息
Department of Medicine, Hospital Universitario Marques de Valdecilla, University of Cantabria, Spain.
出版信息
Diabetes Care. 1993 May;16(5):809-11. doi: 10.2337/diacare.16.5.809.
OBJECTIVE
To determine the levels of intraplatelet cGMP, an index of activity of the antiaggregatory nitric oxide pathway, in IDDM patients.
RESEARCH DESIGN AND METHODS
We measured intraplatelet and plasmatic cGMP levels in 22 IDDM patients and 22 age- and sex-matched control subjects.
RESULTS
Intraplatelet cGMP levels decreased in the IDDM patients (0.32 +/- 0.16 pmol/10(9) platelets) when compared with the control group (0.52 +/- 0.32 pmol/10(9) platelets), P = 0.032. Plasmatic cGMP levels were not significantly different between groups. Intraplatelet cGMP levels correlated negatively with the duration of the disease (r = -0.43, P < 0.05).
CONCLUSIONS
IDDM patients have lower levels of intraplatelet cGMP, which may be responsible in part for their platelet hyperactivity.
目的
测定胰岛素依赖型糖尿病（IDDM）患者血小板内cGMP水平，这是抗聚集一氧化氮途径活性的一个指标。
研究设计与方法
我们测定了22例IDDM患者以及22例年龄和性别匹配的对照者的血小板内和血浆中的cGMP水平。
结果
与对照组（0.52±0.32 pmol/10⁹血小板）相比，IDDM患者的血小板内cGMP水平降低（0.32±0.16 pmol/10⁹血小板），P = 0.032。两组间血浆cGMP水平无显著差异。血小板内cGMP水平与病程呈负相关（r = -0.43，P < 0.05）。
结论
IDDM患者的血小板内cGMP水平较低，这可能部分导致了他们的血小板活性过高。
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