Jubiz W, Carlile S, Lagerquist L D
J Clin Endocrinol Metab. 1977 Feb;44(2):379-82. doi: 10.1210/jcem-44-2-379.
Serum thyroxine (T4), triiodothyronine (T3) and thyrotropin (TSH) concentrations were measured in 13 patients with chronic obstructive pulmonary disease receiving saturated solution of potassium iodide (SSKI). All had a low serum T4 and a high serum TSH concentration. However, serum T3 levels were normal in eight. Recovery of normal thyroid function was observed in each of the seven patients in whom the iodide was discontinued. The same hormones were measured in four normal subjects who received 30 drops of SSKI daily for 11 weeks. An increase in serum TSH levels was preceded by a fall in serum concentrations of T4 and to some extent, T3. Upon SSKI withdrawal subsequent increases in the serum concentrations of both thyroid hormones, but particularly T3, resulted in the return of serum TSH to baseline levels. None of the subjects developed clinical hypothyroidism. It is not apparent why the normal subjects did not exhibit clinical or laboratory evidence of hypothyroidism while the patients with chronic pulmonary disease did. A younger age and the shorter duration of iodide administration in the normal subjects may have played a role.
对13例接受碘化钾饱和溶液（SSKI）治疗的慢性阻塞性肺疾病患者测定了血清甲状腺素（T4）、三碘甲状腺原氨酸（T3）和促甲状腺激素（TSH）浓度。所有患者血清T4水平低而血清TSH浓度高。然而，8例患者的血清T3水平正常。停用碘化物的7例患者中，每例均观察到甲状腺功能恢复正常。对4名正常受试者每天给予30滴SSKI，持续11周，并测定相同的激素。血清TSH水平升高之前，血清T4浓度下降，T3浓度也有一定程度下降。停用SSKI后，两种甲状腺激素，尤其是T3的血清浓度随后升高，导致血清TSH恢复至基线水平。所有受试者均未出现临床甲状腺功能减退。目前尚不清楚为什么正常受试者未表现出临床或实验室甲状腺功能减退的证据，而慢性肺病患者却出现了。正常受试者年龄较小且碘化物给药时间较短可能起到了一定作用。
