Heinze H J, Shulman D I, Diamond F B, Bercu B B
Department of Pediatrics, University of South Florida College of Medicine, Tampa.
Thyroid. 1993 Spring;3(1):37-40. doi: 10.1089/thy.1993.3.37.
Serum thyroglobulin (Tg) data are presented for 47 infants with congenital thyroid disorders. Abnormal elevation of serum Tg (> 250 micrograms/L) occurred in 17% of the population studied, whereas values in excess of 1,000 micrograms/L were demonstrated in 11% of infants. The latter group includes the first report of supraphysiologic Tg elevation in an infant with thyroid gland ectopia, and the highest reported thyroglobulin level in the syndrome of generalized thyroid hormone resistance in an infant homozygous for a novel deletion in the c-erbA beta receptor. Mechanisms involved in the pathogenesis of Tg elevation are discussed. We conclude that Tg elevation in congenital thyroid disorders is more common than previously recognized, and values > 1,000 micrograms/L identify infants with a spectrum of anatomic and biochemical abnormalities.
本文展示了47例先天性甲状腺疾病婴儿的血清甲状腺球蛋白（Tg）数据。在研究人群中，17%出现血清Tg异常升高（>250微克/升），而11%的婴儿血清Tg值超过1000微克/升。后一组包括首次报道甲状腺异位婴儿出现超生理水平的Tg升高，以及一名纯合子c-erbAβ受体新型缺失的婴儿在全身性甲状腺激素抵抗综合征中报告的最高甲状腺球蛋白水平。文中讨论了Tg升高发病机制。我们得出结论，先天性甲状腺疾病中Tg升高比以前认识到的更为常见，且Tg值>1000微克/升可识别出一系列存在解剖学和生化异常的婴儿。
