Guerra F K, Ciuffo G M, Elizalde P V, Charreau E H, Saavedra J M
Institute of Biology and Experimental Medicine, Buenos Aires, Argentina.
Biochem Biophys Res Commun. 1993 May 28;193(1):93-9. doi: 10.1006/bbrc.1993.1594.
Angiotensin II receptors of the AT1 subtype were very highly expressed in medroxyprogesterone-induced ductal adenocarcinomas of the mammary gland in BALB/c mice. AT1 receptors are associated only to neoplastic epithelial cells. Lobular adenocarcinomas expressed very few AT1 receptors and expressed AT2 receptors only in areas corresponding to peritumoral connective tissue. Binding to angiotensin converting enzyme was present in all adenocarcinomas studied and was higher in ductal than in lobular adenocarcinomas. Normal mammary gland did not express either angiotensin II receptors or angiotensin converting enzyme. The present results are the first demonstration of angiotensin receptor subtypes and converting enzyme in mammary adenocarcinomas differentially expressed in tumors of ductal and lobular origin. Localization of receptor subtypes could be useful to study the differentiation of mammary cells during experimental mammary carcinogenesis in mice.
在BALB/c小鼠中，AT1亚型的血管紧张素II受体在甲羟孕酮诱导的乳腺导管腺癌中高度表达。AT1受体仅与肿瘤上皮细胞相关。小叶腺癌表达的AT1受体极少，且仅在肿瘤周围结缔组织对应的区域表达AT2受体。在所研究的所有腺癌中均存在血管紧张素转换酶结合，且导管腺癌中的结合高于小叶腺癌。正常乳腺既不表达血管紧张素II受体，也不表达血管紧张素转换酶。目前的结果首次证明了血管紧张素受体亚型和转换酶在源自导管和小叶的乳腺腺癌中差异表达。受体亚型的定位可能有助于研究小鼠实验性乳腺癌发生过程中乳腺细胞的分化。
