Svaren J, Hörz W
Institut für Physiologische Chemie, Universität München, Germany.
Curr Opin Genet Dev. 1993 Apr;3(2):219-25. doi: 10.1016/0959-437x(93)90026-l.
It is becoming increasingly clear that nucleosome structure is integrally involved in gene regulation. In particular, the study of inducible genes has shown that nucleosomes not only contribute to a repressed basal state, but can also be rearranged in response to induction. The mechanism of this process is just beginning to be elucidated, and genetic studies have implicated several proteins in the modulation of nucleosome structure.
越来越明显的是，核小体结构与基因调控密切相关。特别是，对诱导型基因的研究表明，核小体不仅有助于维持基因的抑制性基础状态，而且还能在诱导作用下发生重排。这一过程的机制刚刚开始被阐明，遗传学研究已经表明有几种蛋白质参与了核小体结构的调节。
