Rofsky N M, Weinreb J C, Bernardino M E, Young S W, Lee J K, Noz M E
Department of Radiology, New York University Medical Center, Tisch Hospital, NY 10016.
Radiology. 1993 Jul;188(1):53-9. doi: 10.1148/radiology.188.1.8390072.
Fifty-eight patients suspected of having focal hepatic disease were studied prior to and following the intravenous administration of manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP), a hepatobiliary magnetic resonance (MR) contrast agent. Four doses (3, 5, 8, or 10 mumol/kg) of Mn-DPDP were used to test the hypothesis that Mn-DPDP-enhanced MR imaging would display enhancement in tumors of hepatocellular origin. A total of 203 lesions were evaluated. Histologic proof was available in 32 cases, and in 26 cases lesions were evaluated on the basis of characteristic imaging findings. Statistical calculations for distinction of tumors of hepatocellular origin yielded a sensitivity of 100%, a specificity of 92.0%, an accuracy of 93.6%, a positive predictive value of 75.9%, and a negative predictive value of 100%. The authors conclude that the presence and patterns of enhancement at Mn-DPDP-enhanced MR imaging permit reliable distinction between hepatocellular and nonhepatocellular tumors.
对58例疑似患有局灶性肝病的患者在静脉注射锰（II）N，N'-二吡啶氧基乙二胺-N，N'-二乙酸5,5'-双（磷酸）（DPDP，一种肝胆磁共振（MR）造影剂）之前和之后进行了研究。使用四剂（3、5、8或10μmol/kg）的锰-二磷酸二吡哆醛来检验锰-二磷酸二吡哆醛增强磁共振成像会显示肝细胞源性肿瘤增强的假设。共评估了203个病灶。32例有组织学证据，26例根据特征性影像学表现评估病灶。区分肝细胞源性肿瘤的统计学计算得出敏感性为100%，特异性为92.0%，准确性为93.6%，阳性预测值为75.9%，阴性预测值为100%。作者得出结论，锰-二磷酸二吡哆醛增强磁共振成像的强化表现和模式能够可靠地区分肝细胞性和非肝细胞性肿瘤。
