从阿黑皮素原到癌症。转化酶在肿瘤形成中的可能作用。
From proopiomelanocortin to cancer. Possible role of convertases in neoplasia.
作者信息
Mbikay M, Seidah N G, Chretien M
机构信息
Laboratory J.A. de Sève de Neuroendocrinologie Moléculaire, Université de Montréal, Québec, Canada.
出版信息
Ann N Y Acad Sci. 1993 May 31;680:13-9. doi: 10.1111/j.1749-6632.1993.tb19671.x.
Abstract
Melanophore-stimulating hormones (MSHs) are produced from a common precursor called proopiomelanocortin (POMC). These peptides have been at the center of studies on the prohormone theory since 1967. The recent discovery of endoproteases which can convert POMC to MSHs is having more biological implications than previously imagined, most particularly for proliferative diseases like cancer.
摘要
促黑素细胞激素（MSHs）由一种名为阿黑皮素原（POMC）的共同前体产生。自1967年以来，这些肽一直是激素原理论研究的核心。最近发现的能将POMC转化为MSHs的内蛋白酶，其生物学意义比之前想象的更大，尤其是对癌症等增殖性疾病而言。
Zotero 插件