Jaffe J P, Bosch A, Raich P C
Cancer. 1979 Jan;43(1):124-8. doi: 10.1002/1097-0142(197901)43:1<124::aid-cncr2820430119>3.0.co;2-n.
Eleven patients with advanced multiple myeloma refractory to standard chemotherapy were treated with a regimen of sequential hemi-body radiotherapy consisting of 800 rad midplane in a single dose to each half. 9/10 patients experienced significant relief of skeletal pain and there were 5/11 objective tumor responses with one complete remission. Treatment-related morbidity was significant and consisted primarily of nausea and emesis, bone marrow suppression, and pneumonitis. This therapy is helpful in the management of advanced myeloma, and should be studied earlier in the course of the disease.
11例对标准化疗难治的晚期多发性骨髓瘤患者接受了序贯半身放疗方案，即每侧单次给予中平面800拉德的剂量。10例患者中有9例骨骼疼痛显著缓解，11例患者中有5例出现客观肿瘤反应，其中1例完全缓解。与治疗相关的发病率较高，主要包括恶心、呕吐、骨髓抑制和肺炎。这种疗法有助于晚期骨髓瘤的治疗，应在疾病进程中更早地进行研究。
