亨廷顿病大鼠喹啉酸模型中的视觉诱发电位
Visual evoked potentials in the rat quinolinic acid model of Huntington's disease.
作者信息
Schwarz M, Block F
机构信息
Department of Neurology, University of Essen, FRG.
出版信息
Neurosci Lett. 1993 Apr 2;152(1-2):81-3. doi: 10.1016/0304-3940(93)90488-7.
Intrastriatal injection of quinolinic acid (QA) in rats induces some of the neuropathological and neurochemical alterations observed in the striatum of patients suffering from Huntington's disease (HD). In addition this animal model mimics the diminution of the amplitude of early cortical somatosensory evoked potentials (SEPs) seen in HD patients. The present study investigated whether the QA model also exhibits abnormalities of early cortical visual evoked potentials (VEPs) observed in HD patients. Two weeks after unilateral intrastriatal injection of QA (240 nmol) early VEPs elicited in response to light flashes were not significantly altered in lightly pentobarbital-anaesthetized rats. It is concluded that (1) the QA animal model of HD does not mimic the VEP abnormalities seen in HD patients, and (2) a striatal lesion does not modulate transmission of visual input to the cortex in rats.
给大鼠脑内纹状体注射喹啉酸（QA）会引发一些在亨廷顿舞蹈病（HD）患者纹状体中观察到的神经病理学和神经化学改变。此外，这种动物模型模拟了HD患者早期皮层体感诱发电位（SEP）波幅减小的情况。本研究调查了QA模型是否也表现出HD患者中观察到的早期皮层视觉诱发电位（VEP）异常。在单侧脑内纹状体注射QA（240 nmol）两周后，在轻度戊巴比妥麻醉的大鼠中，由闪光诱发的早期VEP没有明显改变。得出的结论是：（1）HD的QA动物模型没有模拟出HD患者中看到的VEP异常；（2）纹状体损伤不会调节大鼠视觉输入向皮层的传递。
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