Rogers B B, Mark Y, Oyer C E
Program in Developmental Pathology, Women and Infants' Hospital, Providence, Rhode Island.
Pediatr Pathol. 1993 May-Jun;13(3):371-9. doi: 10.3109/15513819309048224.
This study was undertaken to obtain additional information about the incidence and characteristics of fetal parvovirus B19 infection in an unselected autopsy series, and to assess the distribution and quantitation of inclusions in various organs. Autopsy records from 673 fetal and neonatal autopsies performed at Women and Infants' Hospital during 1985 through 1990 were reviewed. Thirty-two cases of hydrops fetalis were identified, and, of these, 5 had parvovirus infection. This gives an incidence of fetal parvovirus infection resulting in hydrops fetalis of 0.7% among all autopsies, and a 16% incidence among cases of hydrops. Thirty-five percent of the cases of hydrops had malformations; a muscular ventricular septal defect was noted in one of the 5 cases of parvovirus infection. All 5 parvovirus cases had characteristic erythroid nuclear inclusions, and these inclusions were resistant to tissue degenerative changes. The most reliable tissue for histologic diagnosis was the liver, followed by heart and lung. Only 2 of 5 placentas had diagnostic inclusions, making examination of the placenta alone insufficient for ruling out fetal parvovirus infection.
本研究旨在从未经挑选的尸检系列中获取有关胎儿细小病毒B19感染的发生率和特征的更多信息，并评估各器官中包涵体的分布和定量情况。回顾了1985年至1990年期间在妇女和婴儿医院进行的673例胎儿和新生儿尸检的记录。确定了32例胎儿水肿病例，其中5例有细小病毒感染。这使得在所有尸检中，由胎儿细小病毒感染导致胎儿水肿的发生率为0.7%，在水肿病例中的发生率为16%。35%的水肿病例有畸形；在5例细小病毒感染病例中有1例发现肌肉型室间隔缺损。所有5例细小病毒病例都有特征性的红细胞核内包涵体，并且这些包涵体对组织退行性变具有抵抗力。用于组织学诊断最可靠的组织是肝脏，其次是心脏和肺。5个胎盘样本中只有2个有诊断性包涵体，因此仅检查胎盘不足以排除胎儿细小病毒感染。
