基于脊髓灰质炎病毒和鼻病毒结构对柯萨奇病毒B3三级结构的建模。

Modelling of the tertiary structure of coxsackievirus B3 from the structure of poliovirus and rhinovirus.

作者信息

Liljas L, Lindberg A M, Pettersson U

机构信息

Dept. of Molecular Biology and Medical Genetics, Uppsala University, Sweden.

出版信息

Scand J Infect Dis Suppl. 1993;88:15-24.

PMID:8390718

Abstract

The amino acid sequence of the coat proteins of coxsackievirus B3(CB3) was aligned to the sequence of poliovirus and rhinovirus. A model of the tertiary structure of CB3 was built from the known structure of poliovirus 1 and rhinovirus type 14. The CB3 protein shell is predicted to be similar to that of poliovirus and rhinovirus. The model shows that the surface loops which constitute the major immunogenic sites in these viruses are highly exposed also in CB3. Also other features, as the canyon and the "WIN pocket" are also predicted to be conserved in CB3.

摘要

柯萨奇病毒B3（CB3）衣壳蛋白的氨基酸序列与脊髓灰质炎病毒和鼻病毒的序列进行了比对。基于脊髓灰质炎病毒1型和鼻病毒14型的已知结构构建了CB3的三级结构模型。预计CB3的蛋白衣壳与脊髓灰质炎病毒和鼻病毒的相似。该模型显示，构成这些病毒主要免疫原性位点的表面环在CB3中也高度暴露。此外，其他特征，如峡谷和“WIN口袋”预计在CB3中也保守。