Baumann K H, Kiesel L, Kaufmann M, Bastert G, Runnebaum B
Department of Gynaecology and Obstetrics, University of Heidelberg, Germany.
Breast Cancer Res Treat. 1993;25(1):37-46. doi: 10.1007/BF00662399.
Gonadotropin-releasing hormone analogs (GnRH-A) have been added to the armentarium in the therapy of hormone-dependent breast cancer in premenopausal women. The effect of chronic GnRH-A-treatment in premenopausal women is based on the suppression of the hypothalamus-pituitary-ovarian axis and the reduction of sex-steroid serum levels. In addition, a number of experimental and clinical data have been accumulated indicating a direct action of GnRH-A on breast cancer cells and tissue. In this study we analyzed 235 human breast cancer biopsies for specific GnRH-A-binding. We demonstrate high affinity GnRH-A binding sites in human breast cancer tissues. The evaluation of clinical data showed no correlation of the level of GnRH-A-binding with classical tumor parameters.
促性腺激素释放激素类似物（GnRH-A）已被纳入绝经前女性激素依赖性乳腺癌的治疗手段中。绝经前女性长期使用GnRH-A治疗的效果基于下丘脑-垂体-卵巢轴的抑制以及血清性激素水平的降低。此外，已经积累了大量实验和临床数据，表明GnRH-A对乳腺癌细胞和组织有直接作用。在本研究中，我们分析了235份人类乳腺癌活检样本中的特异性GnRH-A结合情况。我们证实在人类乳腺癌组织中存在高亲和力的GnRH-A结合位点。临床数据评估显示，GnRH-A结合水平与经典肿瘤参数之间无相关性。
