[Effect of Asthremedin on bronchial hyperresponsiveness (BHR) to histamine induced by intravenous administration of platelet activating factor (PAF) in guinea pigs].

Platelet activating factor (PAF) has been suggested to play an important role in the pathogenesis of bronchial asthma. In the present study, the effect of i.c. administration of asthremedin on bronchial hyperresponsiveness (BHR) induced by i.v. administration of PAF was investigated in guinea pigs. Changes of airway wall thickness and ratio of bronchial smooth muscle constriction by histamine were calculated from dynamic respiratory resistance. Administration of PAF induced airway wall thickening. The ratio of bronchial smooth muscle constriction by histamine was enhanced by administration of PAF. Asthremedin did not inhibit airway wall thickening by PAF, but inhibited BHR to histamine induced by PAF.