[血栓素A2（TXA2）拮抗剂对豚鼠静脉注射白三烯C4（LTC4）诱导的支气管高反应性的影响]

[Effect of thromboxane A2 (TXA2) antagonists on bronchial hyperresponsiveness induced by intravenous administration of leukotriene C4 (LTC4) in guinea pigs].

作者信息

Yodonawa S, Tsukagoshi H, Kurosawa M

机构信息

First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Feb;31(2):162-8.

PMID:8515595

Abstract

Effects of TXA2 antagonists on bronchial hyperresponsiveness induced by intravenous administration of LTC4 in guinea pigs were investigated by measurement of dynamic compliance and dynamic respiratory resistance, using a formula to exclude the effects of changes in airway wall thickness. With the formula, the ratio of bronchial smooth muscle constriction by histamine can be estimated as an index of bronchial hyperresponsiveness to histamine. Administration of LTC4 induced airway wall edema. The ratio of bronchial smooth muscle constriction by histamine was enhanced by the administration of LTC4. TXA2 antagonists, ONO-NT-126 and ONO-8809, inhibited the increased ratio of bronchial smooth muscle constriction of LTC4. On the other hand, the antagonists showed no significant effects on airway wall edema by LTC4. These results suggest TXA2 may play a role in LTC4-induced bronchial hyperresponsiveness to histamine.

摘要

通过测量动态顺应性和动态呼吸阻力，并使用一个公式来排除气道壁厚度变化的影响，研究了血栓素A2（TXA2）拮抗剂对豚鼠静脉注射白三烯C4（LTC4）诱导的支气管高反应性的影响。使用该公式，组胺引起的支气管平滑肌收缩比率可作为支气管对组胺高反应性的指标进行估算。注射LTC4可诱导气道壁水肿。注射LTC4可提高组胺引起的支气管平滑肌收缩比率。TXA2拮抗剂ONO-NT-126和ONO-8809可抑制LTC4导致的支气管平滑肌收缩比率升高。另一方面，这些拮抗剂对LTC4引起的气道壁水肿无显著影响。这些结果表明，TXA2可能在LTC4诱导的支气管对组胺的高反应性中起作用。