Zanjani E D, Poster J, Burlington H, Mann L I, Wasserman L R
J Lab Clin Med. 1977 Mar;89(3):640-4.
Fetal sheep produced significant amounts of erythropoietin in response to bleeding. Bilateral nephrectomy prior to bleeding failed to influence the formation of erythropoietin. Removal of the spleen, in addition to kidneys, was also without effect. Subtotal hepatectomy prior to bleeding, however, inhibited erythropoietin formation in these fetuses. In situ perfusion of the liver, but not the kidney, resulted in the appearance of significant quantities of the hormone in the perfusate. These results suggest that the liver is the primary site of erythropoietin production in the mammalian fetus.
胎儿绵羊在出血时会产生大量促红细胞生成素。出血前进行双侧肾切除术未能影响促红细胞生成素的形成。除肾脏外，切除脾脏也没有效果。然而，出血前进行次全肝切除术会抑制这些胎儿体内促红细胞生成素的形成。对肝脏而非肾脏进行原位灌注，会使灌注液中出现大量该激素。这些结果表明，肝脏是哺乳动物胎儿促红细胞生成素产生的主要部位。
