Kalra P S, Kalra S P
Department Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville 32610.
Brain Res. 1993 May 7;610(2):330-3. doi: 10.1016/0006-8993(93)91418-r.
We have investigated the effects of the tachykinin, neurokinin A (NKA) and N-terminally extended forms NPK and NP gamma on plasma levels of corticosterone. Both peripheral and central injections of these three NK-2 receptor agonists stimulated adrenal corticosterone release in gonad-intact and castrated male rats. A comparison of their effects revealed that NPK was relatively more potent than NKA and NP gamma. These results suggest that tachykinins may act at both central and peripheral sites to stimulate corticosterone release and that NKA and NP gamma may represent degradation forms of the larger, biologically effective tachykinin, NPK.
我们研究了速激肽、神经激肽A（NKA）以及N端延伸形式的NPK和NPγ对皮质酮血浆水平的影响。对性腺完整和去势雄性大鼠进行外周和中枢注射这三种NK-2受体激动剂，均能刺激肾上腺皮质酮释放。对它们作用效果的比较显示，NPK相对比NKA和NPγ更有效。这些结果表明，速激肽可能在中枢和外周部位均发挥作用以刺激皮质酮释放，并且NKA和NPγ可能是更大的、具有生物学活性的速激肽NPK的降解形式。
