质子泵抑制剂NC - 1300需要胃酸来对大鼠胃黏膜发挥细胞保护作用。

NC-1300, a proton-pump inhibitor, requires gastric acid to exert cytoprotection in rat gastric mucosa.

作者信息

Arakawa T, Fukuda T, Higuchi K, Koike K, Satoh H, Kobayashi K

机构信息

Third Department of Internal Medicine, Osaka City University Medical School, Japan.

出版信息

Jpn J Pharmacol. 1993 Apr;61(4):299-302. doi: 10.1254/jjp.61.299.

DOI:10.1254/jjp.61.299

PMID:8391606

Abstract

Effect of gastric acid suppression on the cytoprotective effect of a single dose of NC-1300 given intragastrically was studied. NC-1300 given intragastrically prevented gastric mucosal damage caused by absolute ethanol in rats in a dose-related manner, while the drug given subcutaneously did not. Pretreatment with NC-1300 given subcutaneously to suppress acid secretion abolished the protective effect of NC-1300 given intragastrically, but not in the presence of 0.1 N HCl. Repeated intragastric administration of NC-1300 for 7 days failed to prevent the ethanol damage. These results suggest that NC-1300 requires gastric acid to exert a protective effect against ethanol in rat gastric mucosa.

摘要

研究了胃酸抑制对胃内给予单剂量NC - 1300的细胞保护作用的影响。胃内给予NC - 1300可剂量依赖性地预防大鼠因无水乙醇引起的胃黏膜损伤，而皮下给予该药物则无此作用。皮下给予NC - 1300以抑制胃酸分泌进行预处理，消除了胃内给予NC - 1300的保护作用，但在存在0.1 N盐酸的情况下则不会。连续7天重复胃内给予NC - 1300未能预防乙醇损伤。这些结果表明，NC - 1300需要胃酸才能对大鼠胃黏膜的乙醇损伤发挥保护作用。