Snow J B, Naunton R F
Department of Health and Human Services, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892.
ORL J Otorhinolaryngol Relat Spec. 1993 May-Jun;55(3):154-8. doi: 10.1159/000276411.
Promising fundamental research opportunities identified by the National Strategic Research Plan of the National Institute on Deafness and Other Communication Disorders include encoding of sound and gravitational/acceleration force by the inner ear, processing complex signals in the central nervous system, the molecular and cellular mechanisms responsible for hair cell motility, mechanoelectric transduction, homeostasis and metabolism of the inner ear, synaptic transmission, hair cell regeneration, plasticity and otoacoustic emissions. Clinical research opportunities include the molecular genetics of hereditary hearing impairment, the etiology of sensorineural hearing loss, environmental ototoxicity, the elucidation of tinnitus, the development of vaccines against otitis media, pharmacotherapy, rehabilitation for hearing loss and deafness with hearing aids and cochlear implants and physical therapy rehabilitation for vestibular disorders.
美国国立耳聋及其他交流障碍研究所的《国家战略研究计划》确定的有前景的基础研究机会包括内耳对声音和重力/加速力的编码、中枢神经系统中复杂信号的处理、负责毛细胞运动、机械电转导、内耳内环境稳定和代谢、突触传递、毛细胞再生、可塑性和耳声发射的分子和细胞机制。临床研究机会包括遗传性听力障碍的分子遗传学、感音神经性听力损失的病因、环境耳毒性、耳鸣的阐明、中耳炎疫苗的研发、药物治疗、使用助听器和人工耳蜗对听力损失和耳聋的康复以及前庭疾病的物理治疗康复。
