Hall W W, ter Meulen V
J Gen Virol. 1977 Feb;34(2):391-6. doi: 10.1099/0022-1317-34-2-391.
The effect of actinomycin D on the production of genomic RNA, messenger RNA and protein in measles virus-infected cells were investigated. It was found that whereas high concentrations of the drug inhibited genome synthesis, the production of messenger RNA was unaffected and in some cases enhanced. These effects were shown, at least in part, to be due to a secondary effect of the drug which caused an inhibition of virus-specific protein synthesis.
研究了放线菌素D对麻疹病毒感染细胞中基因组RNA、信使RNA和蛋白质产生的影响。结果发现，高浓度的该药物抑制基因组合成，而信使RNA的产生未受影响，在某些情况下还有所增强。这些效应至少部分是由于该药物的继发效应，即它导致了病毒特异性蛋白质合成的抑制。
