Keymeulen B, Somers G
Departement Interne Geneeskunde, AZ VUB, Brussel, België.
Acta Clin Belg. 1993;48(2):86-95. doi: 10.1080/17843286.1993.11718292.
The hitherto identified hallmarks of the autoimmune aspects in Type 1 diabetes are reviewed. Their implication in the disclosure of the pre-clinical phase of the disease is put forward. The possible delineation of this pre-diabetic phase can lead to an early immunotherapeutic approach. The effect of immunomodulation by agents such as azathioprine, cyclosporin A and nicotinamide in newly diagnosed diabetes and the use of some of these drugs in clinical trials on pre-diabetic individuals are discussed.
本文回顾了迄今已确定的1型糖尿病自身免疫方面的特征。提出了它们在疾病临床前期发现中的意义。对糖尿病前期阶段的可能界定可带来早期免疫治疗方法。讨论了硫唑嘌呤、环孢素A和烟酰胺等药物在新诊断糖尿病中的免疫调节作用，以及其中一些药物在糖尿病前期个体临床试验中的应用。
