[酒精与游离氧自由基]
[Alcohol and free oxygen radicals].
作者信息
Mira M L, Manso C F
机构信息
Instituto de Química Fisiológica, Faculdade de Medicina, Lisboa.
出版信息
Acta Med Port. 1993 May;6(5):193-8.
Oxygen free radicals may be generated during ethanol metabolization by cytochrome P450, or due to the formation of xanthine oxidase by ethanol effect on xanthine dehydrogenase. After transformation into acetaldehyde, the metabolism of this compound by xanthine oxidase or by aldehyde oxidase also generates oxygen radicals. We present the hypothesis of a vicious cycle during ethanol metabolization by aldehyde oxidase, which would amplify the process and be responsible for an increased degree of lipid peroxidation.
氧自由基可能在乙醇通过细胞色素P450代谢过程中产生，或者由于乙醇对黄嘌呤脱氢酶的作用形成黄嘌呤氧化酶而产生。转化为乙醛后，该化合物通过黄嘌呤氧化酶或醛氧化酶的代谢也会产生氧自由基。我们提出了醛氧化酶在乙醇代谢过程中存在恶性循环的假说，这将放大该过程并导致脂质过氧化程度增加。
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